Natural product screening programs have uncovered molecules from diverse natural sources with various biological activities and unique structures.However, much is yet underexplored and additional information is hidden in these exceptional collections.We applied untargeted mass spectrometry approaches to capture the chemical space and dispersal patt
Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
Abstract Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells.Through high-resolution replication sequencing and a capture-ligation assay in mouse neural ENDURA STRESS PET progenitor cells experiencing replication stress, we unravel the replication features dictating RDC lo
William Faulkner (1897-2003) some reflections on Absalom, Absalom!
The moral malaise that afflicts the inhabitants of the American South in the twentieth century and the origin of that trauma for the crime of slavery are addressed in Absalom, Absalom! (1,936).Through Thomas Sutpen, the 3ag/5ag Fuses tragic hero of the piece, and its history, the existing truth is questioned after the Confederate myth, so we can ju
Treatment of avian malaria in captive African penguins (Spheniscus demersus) by the combination of atovaquone and proguanil hydrochloride
Avian malaria, a vector-borne disease caused by Plasmodium spp., poses significant threats to various bird populations, particularly captive penguins like the endangered African penguin (Spheniscus demersus).Penguins, originating from regions with low malaria prevalence, are highly susceptible when housed in malaria-permissive areas.This study eval
Evaluating the removal efficiency of emerging contaminants in a gravity-driven membrane bioreactors GD-MBR under various aeration conditions for primary wastewater treatment
Conventional wastewater treatment processes have shown limited efficiency in removing emerging contaminants (EC), including organic micropollutants (OMPs) thus posing risks due to the safe discharge and reuse of wastewater effluent due to the presence of antibiotic-resistant bacteria and antibiotic resistance genes (ARG).Membrane technologies are b